Manufacturer
DUOPHARMA (M) SDN. BHD.
 
Contents
Atropine sulphate
 
Indication
Pre-anaesth medication in conjugation w/ morphine sulphate. Reverse the effects of non-depolarising muscle relaxants in conjugation w/ neostigmine methyl sulphate. Smooth muscle spasm in conditions eg, renal & biliary colic. Management of arrhythmias & treatment of bradycardia or asystole due to overdosage w/ parasympathomimetic agents. Suppression of GI motility in the treatment of peptic ulcer. Diagnosis of colicky pain. Antidote in carbamate & w/ pralidoxime in organophosphorus insecticide poisoning.
 
Instruction
IV Management of arrhythmias 400 mcg-1 mg, repeated as needed to a total dose of 2 mg. SC/IM/IV Bradycardia or asystole due to overdosage w/ parasympathomimetic agents 1-2 mg. IV/IM Anticholinesterase poisoning 1-2 mg initial dose for mild poisoning; 6 mg as often as every 5 min for severe poisoning. SC/IM/IV Adult GI anticholinergic effect 400-600 mcg qds. Pre-anaesth medication 300-600 mcg 1 hr before induction. SC Childn 10 mcg/kg every 4-6 hr (w/ reduced doses on hot days or for a febrile child).
 
Drug interaction
Enhanced effect w/ other antimuscarinic agents eg, amantadine, some antihistamines, butyrophenones, phenothiazines & TCAs.