Manufacturer
Mylan
 
Contents
Per 1.2 g powd for inj Amoxicillin 1 g, clavulanic acid 200 mg
 
Indication
Short-term treatment for upper & lower resp tract, GUT, skin & soft tissue, bone & joint infections.
 
Instruction
Adult & childn >12 yr 1.2 g every 8 hr, may be increased to every 6 hr. Childn 3 mth-12 yr 30 mg/kg every 8 hr, may be increased to every 6 hr, 0-3 mth 30 mg/kg every 12 hr, may be increased to every 8 hr thereafter. Moderate renal impairment (CrCl 10-30 mL/min) 1.2 g IV stat followed by 600 mg IV every 12 hr. Severe renal impairment (CrCl <10 mL/min) 1.2 g IV stat followed by 600 mg IV every 24 hr. Additional 600 mg IV may need to be given during & at the end of dialysis.
 
Drug interaction
Prolonged bleeding & prothrombin time w/ anticoagulant therapy. Reduced efficacy of OCs. Decreased renal tubular excretion by probenecid. Increased allergic skin reactions w/ allopurinol.