Manufacturer
Eisai Manufacturing Limited
 
Contents
Perampanel
 
Indication
Adjunctive treatment of partial-onset seizures w/ or w/o secondarily generalized seizures in patients ≥12 yr w/ epilepsy & primary generalised tonic-clonic seizures in adult & adolescent patients from 12 yr w/ idiopathic generalised epilepsy.
 
Instruction
May be taken with or without food: Swallow whole, do not chew/crush/split.
 
Drug interaction
Decreased levonorgestrel exposure. Increased clearance by CYP450 3A enzyme inducers eg, carbamazepine, phenytoin, oxcarbazepine. Reduced levels by carbamazepine. Decreased oxcarbazepine clearance. Decreased midazolam AUC. Decreased conc by strong CYP450 inducers eg, rifampicin, Hypericum perforatum (St. John's wort); felbamate. Increased AUC & prolonged t_½ by ketoconazole. Additive effects w/ alcohol.